Molecular Epidemiology of Rhodococcus equi Based on traA, vapA, and vapB Virulence Plasmid Markers
نویسندگان
چکیده
منابع مشابه
Evolution of the Rhodococcus equi vap pathogenicity island seen through comparison of host-associated vapA and vapB virulence plasmids.
The pathogenic actinomycete Rhodococcus equi harbors different types of virulence plasmids associated with specific nonhuman hosts. We determined the complete DNA sequence of a vapB(+) plasmid, typically associated with pig isolates, and compared it with that of the horse-specific vapA(+) plasmid type. pVAPB1593, a circular 79,251-bp element, had the same housekeeping backbone as the vapA(+) pl...
متن کاملDetection of vapN in Rhodococcus equi isolates cultured from humans
Rhodococcus equi can cause severe infections in people, particularly in immunocompromised individuals. The R. equi virulence plasmids (vap) encoding vapA and vapB are linked to development of infections in domestic animals. Recently, a novel virulence plasmid, vapN, was identified in isolates cultured from cattle, but its prevalence or significance in human R. equi infections has not been exten...
متن کاملThe vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi.
The virulence plasmid of the pathogenic actinomycete Rhodococcus equi is essential for proliferation of this pathogen in macrophages and the development of disease. The pathogenicity island of this plasmid encodes a family of virulence-associated proteins (Vap), one of which (VapA) is a virulence factor. This paper describes the vcgAB operon (vapA co-expressed gene), located upstream of the vap...
متن کاملDevelopment of Hyperimmune Equine Plasma to Virulence Associated Protein A (VapA) of Rhodococcus equi
Procedure – A proprietary formulation of ATCC 33701 Rhodococcus equi known to contain the virulence plasmid was developed and tested on 72 horses. Antibody levels to Rhodococcus equi Virulence associated protein A (VapA) were determined relative to a Standard Plasma. A clinical trial was performed on 28 foals. Seven foals were administered hyperimmune plasma and seven foals were administered pu...
متن کاملRhodococcus equi: Pathogenesis and Virulence
Inhalation of the facultative intracellular bacterium, Rhodococcus equi, can result in a severe pyogranulomatous pneumonia in young horses and immunocompromised people. This organism is able to resist innate immune defenses and establish residence within the intracellular environment of the alveolar macrophage. Virulence determinants of R. equi have yet to be fully elucidated, but all equine is...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2007
ISSN: 0022-1899,1537-6613
DOI: 10.1086/519688